Defining a cell’s ‘type’ by the RNA transcripts it expresses is popular in biological research, but evidence from zebrafish neurons suggests that transcriptionally similar cells can be functionally diverse. Transcriptionally similar neurons can be functionally diverse.
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Ever since the cell was recognized as the basic unit of life almost 200 years ago, biologists have been on a quest to characterize and classify the myriads of distinct cell types that make up each organ and organism. Since the nineteenth-century drawings of neurons by the neuroscientist Santiago Ramón y Cajal, the brain has been appreciated as the most complex organ, even though morphology was the only accessible criterion for distinguishing neurons. The past decade has seen rapid advancements in technology to classify neurons both functionally, by recording their activity patterns, and molecularly, on the basis of the genes they express. However, there is a disconnect between the current molecular, morphological and functional descriptions of cells in most nervous systems.DEPARTMENT OF DERMATOLOGY BRIGHAM AND WOMEN’S HOSPITAL HARVARD MEDICAL SCHOOL The Kupper laboratory in the Department of Dermatology at Brigh...Faculty positions in Center for Interdisciplinary Studies , Westlake UniversityFaculty Positions, Aging and Neurodegeneration, Westlake Laboratory of Life Sciences and Biomedicine
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