The Cupido Laboratory at St. Jude Children's Research Hospital seeks a postdoctoral research associate to investigate the role of RNA-based processes in shaping cancer genomes. The position will focus on uncovering the molecular links between RNA-based machinery functions and gene transcription regulation using cutting-edge techniques.
The Cupido Laboratory at St. Jude Children's Research Hospital is seeking a highly motivated and talented Postdoctoral Research Associate to investigate the crucial role of RNA -based processes in shaping cancer genomes. This exciting opportunity will focus on uncovering the molecular links between fundamental RNA -based machinery functions and gene transcription regulation.
The successful candidate will utilize a cutting-edge combination of techniques, including genome editing, next-generation sequencing, and chemical and molecular biology approaches. Recent research has illuminated the significance of RNA-based processes in nuclear organization and overall genome function. However, our understanding of these mechanisms remains comparatively limited compared to DNA-templated activities. Notably, large-scale functional genomics efforts have highlighted the specific contribution of RNA-dependent molecular machines to aberrant gene transcription programs observed in cancer cells. This presents a unique opportunity for groundbreaking discoveries in cancer biology and the development of novel therapeutic strategies.The Cupido Laboratory specializes in developing and applying innovative chemical biology approaches to delve into and target the molecular mechanisms underlying cancer genome re-wiring. Research within the lab adopts a highly interdisciplinary approach, seamlessly integrating chemistry with structural, biochemical, and cell biology techniques. The successful candidate will play a key role in leading research endeavors and will leverage functional genomics and cell biology studies to elucidate and characterize the functions of ribonucleoprotein machines in regulating gene expression. Essential prerequisites include creativity, a strong work ethic, and the ability to collaborate effectively in a small team setting. The position also involves regular collaborations with trainees and staff scientists in partner laboratories, fostering a highly interdisciplinary environment that prioritizes career development. Applicants are expected to hold a Ph.D. in biochemistry, molecular biology, computational biology, or a closely related field. A distinguished academic record and a genuine interest in cancer genome organization and function are essential. Prior experience with next-generation sequencing and quantitative cellular and molecular biology techniques is crucial for capitalizing on the project's potential. Familiarity with chemical biology and microscopy techniques would be highly advantageous. St. Jude Children's Research Hospital prides itself on its diverse, global patient population and workforce. Guided by the principles of diversity, equity, and inclusion, the hospital's mission, established by its founder Danny Thomas, is to provide treatment to children worldwide, irrespective of their race, religion, or familial financial situation. Today, St. Jude continues to advance cures and prevention strategies for pediatric catastrophic diseases through groundbreaking research and clinical care. As the hospital expands its global efforts, the commitment to diversity, equity, and inclusion remains a cornerstone of its success. At all organizational levels, leaders are dedicated to ensuring that St. Jude's culture, leadership practices, and talent acquisition processes are equitable and culturally responsive. For further insights into the hospital's rich history in diversity, equity, and inclusion, its current standing, and its aspirations for an even brighter future, please visit the provided link. St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms regarding employment opportunities. Please refrain from contacting the institution via phone or email. Any resumes submitted by search firms to employees or representatives at St. Jude through email, the internet, or any other format and/or method without a valid written search agreement in place and approved by Human Resources will not result in a fee being paid should the candidate be hired by St. Jude
RNA Cancer Genomics Postdoctoral Research St. Jude Chemical Biology Next-Generation Sequencing Gene Transcription
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