A team of chemists has made significant strides in the field of mechanically interlocked molecules (MIMs). Their work showcases the development of a compact catenane with tuneable mechanical chirality, offering promising applications in areas such as material science, nanotechnology, and pharmaceuticals.
A team of chemists has made significant strides in the field of mechanically interlocked molecules . Their work showcases the development of a compact catenane with tuneable mechanical chirality, offering promising applications in areas such as material science, nanotechnology, and pharmaceuticals.
A team of chemists from The University of Hong Kong , in collaboration with international scientists, has made significant strides in the field of mechanically interlocked molecules . Their work, recently published in the prestigious journal, showcases the development of a compact catenane with tuneable mechanical chirality, offering promising applications in areas such as material science, nanotechnology, and pharmaceuticals. The research was a collaborative effort led by the late Nobel Laureate Professor Fraser STODDART, alongside Research Assistant Professors Dr Chun TANG and Dr Ruihua ZHANG from HKU's Department of Chemistry. Contributions also came from researchers at HKU, Northwestern University and other global institutions.Catenanes are unique molecular structures formed by the mechanical interlocking of two or more rings, akin to chain links. Unlike covalent bonds, these rings are held together by mechanical forces. Mechanical chirality refers to the chirality arising from the non-superimposable spatial arrangement of interlocked molecular rings, which can significantly impact their properties and functions. In this study, researchers demonstrated that two achiral rings with specific symmetrical features can create a catenane with mechanical chirality through an innovative isostructural desymmetrisation strategy. This allows the catenane to adopt a compact co-conformation, similar to its achiral counterpart. When interlocked in this compact form, the rings lose their individual symmetry and form chiral structures that cannot overlap with their mirror images, a property known as chirality in chemistry.The research team has developed a catenane with tuneable chirality, achieved through chiral induction and advanced synthetic techniques. By introducing chiral disulfonate molecules, they can favour one mirror-image form over the other, allowing precise control over the catenane's behaviour in solutions and solid crystals. This tunability, driven by a compact design and strategic molecular geometry adjustments, suggests promising applications in smart materials, and nanotechnology and novel drug design. Computational modelling and experimental validation have enabled the manipulation of chirality by controlling the interaction and mechanical movements of the interlocked rings, allowing transitions between different chiral states. The researchers also revealed that the equilibrium between these enantiomers can be adjusted by introducing certain chiral molecules, inducing chirality and optical activity.In nanotechnology, these catenanes could be used to create molecular machines with specific chiral functionalities that perform tasks such as molecular recognition or targeted drug delivery. In materials science, the tunable properties of these structures could lead to the development of new materials and composites with customisable mechanical and optical characteristics for sensing and other applications. "The ability to create and control mechanical chirality in catenanes opens up new avenues for the development of advanced functional materials and artificial molecular machines," said Dr Tang."Our findings highlight the potential of using mechanical bonds to create chirality, which could have important implications for the field of chemistry and materials science."Chun Tang, Ruihua Zhang, Sultan Almunif, Partha Jyoti Das, Paige J. Brown, Ryan M. Young, Guangcheng Wu, Han Han, Xueze Zhao, Arthur H. G. David, Huang Wu, Bo Song, Alexandre Abhervé, Yong Wu, Yu-Meng Ye, Yuanning Feng, Aspen X.-Y. Chen, Charlotte L. Stern, Zhi Li, Evan A. Scott, Michael R. Wasielewski, J. Fraser Stoddart.Resembling the interlocking links in chainmail, novel nanoscale material is incredibly strong and flexible. The interlocked material contains 100 trillion mechanical bonds per 1 square centimeter -- ... Scientists have made significant strides in understanding the properties of a ferroelectric material under an electric field. This breakthrough holds potential for advances in computer memory, lasers ... New research by an international team of chemists describes a new type of artificial cell that can communicate with other cells within the body -- with potential applications in the field of smart ... Chirality is a fundamental property of many organic molecules and means that chemical compounds can appear in not only one form, but in two mirror-image forms as well. Chemists have now found a way ...Astronomers Observe Largest Ever Sample of Galaxies Up to Over 12 Billion Light Years Away
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