The clumping of proteins is at the root of a wide range of neurodegenerative disorders that affect the brain such as Alzheimer's and dementia. Researchers have now developed a new tool that can help find and study these tiny protein clumps.
The clumping of proteins is at the root of a wide range of neurodegenerative disorders that affect the brain such as Alzheimer's and dementia. Researchers have now developed a new tool that can help find and study these tiny protein clumps. The results pave the way for a greater understanding of the body's smallest building blocks and better treatment of diseases like cancer, Alzheimer's and Parkinson's.
"In just minutes, our algorithm solves a challenge that would take researchers several weeks. That it will now be easier to study microscopic images of clumping proteins will hopefully contribute to our knowledge, and in the long term, lead to new therapies for neurodegenerative brain disorders," says PhD Jacob Kæstel-Hansen from the Department of Chemistry, who, alongside Nikos Hatzakis, led the research team behind the algorithm.
In the future, the algorithm will make it much easier to learn more about why clumps form so that we can develop new drugs and therapies to combat these disorders. Thus, the researchers see great potential in being able to use the tool to develop new drugs once the microscopic building blocks have been clearly identified. The researchers hope that their work will kickstart the gathering of more comprehensive knowledge about the shapes and functions of proteins and molecules.
The research was conducted by: Steen W.B. Bender, Marcus W. Dreisler, Min Zhang, Jacob Kæstel-Hansen and Nikos S. Hatzakis from the Department of Chemistry with support from the Novo Nordisk Foundation Center for Optimised Oligo Escape and Control of Disease.Major advance promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer's ...
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