Science, Space and Technology News 2024
UC San Diego researchers have linked lipid metabolism changes to Alzheimer’s disease progression, identifying potential new treatments by targeting the AMPK enzyme to disrupt a cycle of brain inflammation.
In the brain, lipids come in the form of tiny droplets that control a variety of processes, such as energy storage and cellular responses to stress. These processes are tightly regulated in typical brains, but in Alzheimer’s or similar diseases, lipid droplet metabolism can malfunction. While scientists understand that there is a relationship between Alzheimer’s and lipid metabolism, exactly how they influence one another has remained a mystery.
“Instead of using a typical chemical dye to stain lipids, we use heavy water that is naturally participating in the metabolic activities we’re interested in,” added Shi. “This gives us a much clearer picture of how lipids are formed spatiotemporally, which would not be possible with other approaches. Our current focus is on comprehending the underlying mechanisms of these dynamic changes of lipid metabolism in the context of aging and diseases.
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