Science, Space and Technology News 2024
New research shows that post-mitotic neurons in the brain, especially in Alzheimer’s patients, can re-enter the cell cycle and become senescent, potentially offering insights into neurodegeneration and a new method for studying brain diseases.
This uncommon process is more frequently observed in neurodegenerative diseases and could offer insights into disease mechanisms.by Kim Hai-Man Chow and colleagues from the Chinese University of Hong Kong, neurons in the brain that re-enter the cell cycle after mitosis are prone to quick senescence, a process observed more frequently indisease.
Most neurons in the brain are post-mitotic, meaning they have ceased to divide. For many years, it had been assumed that this post-mitotic state was permanent. Recent discoveries have shown that a small proportion of neurons re-enter the cell cycle, but little is known about their fate after they do.
Summary image of the article. The upper part highlights neuronal cell cycle re-engagement is a stage proceeding neuronal senescence and that their full molecular profiles can now be identified by the bioinformatics pipeline we reported in the accepted manuscript. The bottom part is a simplified version of Figure 1A from the paper. The upper panel is created by the BioRender application.
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