Women with pregnancies after a systemic sclerosis diagnosis face higher risks for adverse pregnancy outcomes, with some risks also higher in prediagnosis pregnancies.
Women with systemic sclerosis faced higher risks for adverse pregnancy outcomes such as preeclampsia and preterm birth in a Swedish cohort study. A population-based cohort study based on data from Swedish national health registers from 1987 to 2021 assessed pregnancy outcomes in women with and without systemic sclerosis .
Pregnancies were classified as those occurring before or after SSc diagnosis, with further classification as those occurring 0-3 years before diagnosis or more than 3 years before diagnosis. A total of 972 pregnancies in women with SSc were identified and matched with 1440 and 10,118 comparator pregnancies in women without SSc from the general population.Postdiagnosis pregnancies showed increased risks for preeclampsia , preterm birth , and cesarean delivery . Primiparous women with SSc had a 7.5-fold increased risk for preeclampsia and a 5.1-fold increased risk for preterm birth. Pregnancies within 0-3 years before SSc diagnosis showed increased odds of preterm birth and small-for-gestational-age births . Pregnancies that occurred more than 3 years before SSc diagnosis showed increased odds of preeclampsia and preterm birth ."Our observations highlight the need for multidisciplinary maternal care and pre-pregnancy counseling also for today's women with SSc, with a special focus on primiparous women for the risks are the highest," the authors wrote.The study was led by Weng lan Che, PhD, Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet in Stockholm, Sweden. It wasThis study was supported by the Dr Margaretha Nilsson Foundation, the Swedish Research Council, and the Swedish Cancer Foundation. One author declared being a member of the medical advisory board of the Myositis Association, and another declared part-time employment at the Swedish Medical Products Agency. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our
CREST Syndrome Pregnancy Pregnant High-Risk Pregnancy Premature Birth Preterm Birth Birth Systemic Sclerosis Diffuse Scleroderma Pre-Eclampsia Preeclampsia Toxemia Of Pregnancy Toxaemia Of Pregnancy Facial Cesarean Delivery Caesarean Delivery Cesarean Section Caesarean Section C-Section Arthritis Joint Inflammation Artificial Intelligence Deep Learning AI NPL
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