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The international team of researchers analyzed brain scan data from 85 individuals with 22q11.2 deletion syndrome , a genetic condition that comes with a significantly increased likelihood of Because 22q11DS is linked to both a higher chance of psychosis and disruptions to different parts of the glymphatic system , that may impair the glymphatic system, leading to a build-up of waste products that in turn affect the brain .
and gamma-aminobutyric acid need to be carefully balanced. But in this study, those with less effective glymphatic systems – measured by lower water flow and lower ALPS scores – showed far more excitatory signals than calming ones. "Excessive excitation can become toxic to neurons and contribute to alterations in certain brain regions that are particularly vulnerable and involved in psychosis, such as the hippocampus,"A malfunctioning glymphatic system is by no means exclusive to 22q11DS, but through this small group of participants, the researchers managed to gather some vital new clues about how poor 'brain cleaning' could be a factor If the warning signs hinted at here do indeed emerge early in life, it may mean there are opportunities to intervene before symptoms develop. Further studies of this critical window in development could also reveal more about how psychotic conditions develop in the first place.such as hallucinations ) after they've started appearing. With further research and development, we could now be on the way to finding treatments that take a more proactive and preventative approach. "Identifying such modifiable predictive factors could pave the way for strategies to delay or even prevent a first psychotic episode,"
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