Treatment with adalimumab was associated with improvements in common hematologic abnormalities in patients with hidradenitis suppurativa, particularly in responders.
HS is a chronic inflammatory skin condition characterized by a high inflammatory burden and hematologic abnormalities such as anemia, leukocytosis, and thrombocytosis. Immunomodulatory therapy was previously found to improve hematologic abnormalities in a small To evaluate whether adalimumab therapy was associated with clinical improvement and reductions in hematologic abnormalities, a post hoc analysis of two phase 3 randomized controlledof adalimumab, a tumor necrosis factor blocker, evaluated 633 patients with moderate to severe HS, randomized to receive 40-mg adalimumab weekly or placebo for 12 weeks.
Researchers identified 252 patients in the studies with at least one hematologic abnormality at baseline and divided them into four groups based on their treatment assignment and HS Clinical Response status at 12 weeks: Adalimumab responders and nonresponders and placebo responders and nonresponders .Among the 123 patients who received adalimumab, including nonresponders, significant improvements were observed in mean changes in hemoglobin levels , platelet count . Those on placebo did not have significant improvements in these three parameters.< .001 for all). The association between clinical response with adalimumab and degree of improvement in hemoglobin was borderline significant."Adalimumab, regardless of HiSCR responder status, was associated with improvements in common hematologic abnormalities," the authors wrote, adding that"these findings highlight the high inflammatory load in patients with HS and the frequent occurrence of inflammation-related dyscrasias, which may warrant aggressive management."This study was limited by its sample size, and more research is needed to validate the generalizability of the results.This study was supported by Harvard Catalyst Clinical and Translational Science Center and financial contributions from Harvard University and its affiliated academic healthcare centers. Four authors reported receiving personal fees and grants outside this work. No other disclosures were reported by the authors.All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
Skin And Soft Tissue Infection Anemia Anaemia Platelet Count PLT - Platelet Count Thrombocyte Count Platelets Thrombocytes Hemoglobin Hb Hemoglobin Hgb Hb - Hemoglobin Leukocytosis Thrombocytosis White Blood Cell Count Leukocyte Count WBC Count White Count Blood Grant Translational Research Translative Research Translational Science Tumor
Trending
A gorgeous April afternoon in store across the Denver metro area 
‘Artemis Mission Cannot Lead To Interplanetary Wild West,’ Astronomer Warns 
Trump says US forces will ‘finish the job’ soon in first prime-time speech since starting Iran war 
Former Wisconsin football player, who left the sport amid mental health struggles, dead at 24 
Drew McIntyre Gives Honest Take About His Recent WWE Title Reign 
U.S. Sen. Bernie Sanders introduces bill that could keep the Padres in San Diego United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Covid-19 Vaccination Associated With Reductions In Pediatric Cases & HospitalizationsAnuradha Varanasi is a freelance science writer. She writes on the intersection of health/medicine, racial disparities, and climate change. She earned an MA in Science Journalism from Columbia University in New York City.
Read more »
Metabolic Dysfunction-Associated Steatotic Liver Disease Plus HIV Ups Risk for CVD but Not Liver DiseaseA large study reveals an increased risk for adverse cardiovascular events but not for liver disease progression in adults with MASLD disease and HIV infection.
Read more »
Prurigo Nodularis Associated With Elevated Cardiovascular, Mortality Risks'The potential risk of subsequent cardiovascular disease should be considered in the care of patients with PN,' according to the study authors.
Read more »
Fungal resistance in plants associated with heritable differences in microbiota abundancesSunflowers aren't just beautiful symbols of summer—they are also economically significant, ranking as the fourth most important oilseed crop in the world, and new research suggests that some bacteria might help protect the crop from white-mold destruction.
Read more »
FDA OKs High-Concentration of Adalimumab Biosimilar CyltezoUnlike the low-concentration formulation of adalimumab-adbm, launched July 1, 2023, this high-concentration version has not yet been granted an interchangeability designation.
Read more »
Mars Loaded With Mineral Closely Associated With Life, NASA Rover FindsScience and Technology News and Videos
Read more »