'The potential risk of subsequent cardiovascular disease should be considered in the care of patients with PN,' according to the study authors.
A large international cohort study identified a higher risk for cardiovascular disease s and mortality in patients with prurigo nodularis , particularly among women and White patients.Studies have reported increased risks for cardiovascular disease s in patients with PN, but limited sample sizes have hindered further subgroup analysis. Given PN's pronounced sex and ethnicity skew, it is important to examine underrepresented groups to accurately assess their cardiovascular risk .
In this propensity-score matched analysis, researchers identified 64,801 patients with PN using electronic health reports from the Global Collaborative Network of TriNetX and matched to individuals without PN. Researchers calculated risks for 15 cardiovascular endpoints and all-cause mortality within 10 years of diagnosis. Major adverse cardiovascular events included acute cerebral and myocardial infarction , heart failure, ventricular arrhythmia, and sudden cardiac death.
Women exhibited a higher risk for MACE, heart failure, peripheral artery disease, acute MI, conduction disease, and valve disorders, while men did not have an increased risk for major or acute cardiovascular events. Both men and women had a higher risk for death, chronic ischemic heart disease, and venous disease.
Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Atherosclerotic Heart Disease Atherosclerotic Cardiovascular Disease Coronary Heart Disease Ischemic Heart Disease Coronary Artery Disease Heart Failure Cardiovascular Disease Cvd - Cardiovascular Disease Heart Prurigo Nodularis Arrhythmia Peripheral Vascular Disease
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