Mark Kris discusses clinical trial design and the goal of cure in non–small cell lung cancer.
Professor, Department of Medicine, Weill Cornell Medical College; Attending Physician, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NYServe as a director, officer, partner, employee, advisor, consultant, or trustee for: AstraZeneca; Roche/Genentech; Ariad Pharmaceuticals
The second thing that was brought up is that there's been tremendous progress there. People are living longer and better with the therapies we have, including chemotherapy, checkpoint inhibitors, targeted drugs, surgery, and radiation. All those modalities have advanced and clearly have led to better outcomes.
Pretty much all these regimens used a 1-year timeframe. Is that the best one? Well, the truth is, we don't know for sure, and we do need to know. Obviously, we don't want to overtreat people. However, we do want to give them the most effective therapy we can. The only way to do that is to design trials that can do it.
The last thing is that no one modality can affect cure and can lead to the best outcomes. It's going to be the whole regimen together. I think each person in care team — the surgeon, the medical oncologist, and the radiation oncologist — needs to explain to the patient that the regimen we're recommending has the best chance of providing cure. I may deliver one part of the regimen, but ultimately, what I think can cure the patient is the whole regimen.
Nsclc Lung Cancer Lung Carcinoma Cancer Of The Lung Small Cell Lung Cancer Small-Cell Lung Cancer Oat Cell Lung Cancer SCLC Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study Double-Blind Studies Single-Blind Study Single-Blind Studies
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