Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.
Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.
To develop new mouse strains that accurately reflect the full complexity of Alzheimer's disease, Carter's team drew on recent genome-wide studies that have identified over 70 genes associated with the illness. Using CRISPR gene editing, they collaborated with Sasner and Howell at JAX to introduce different genetic factors associated with Alzheimer's into 11 separate strains of mice, and raised the mice to maturity to explore how the genetic variants affected their brain health.
Using transcriptomics also creates a clearer benchmark for testing new therapeutics: if a treatment aims to prevent inflammation associated with Alzheimer's, for instance, it's possible to evaluate its impact on the transcriptome signature specifically associated with inflammation."This approach can assess whether a treatment is working at the molecular level, without worrying so much about behavioral changes that are hard to spot in mice," said Carter.
"We know how valuable it would be to have a mouse model for Alzheimer's disease," he added."This research is bringing that goal within reach."Michael Sasner, Christoph Preuss, Ravi S. Pandey, Asli Uyar, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter.
Healthy Aging Genes Alzheimer's Dementia Disorders And Syndromes Mice Rodents Genetically Modified
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