Recently, a research team established a comprehensive procedure for isolating primary mouse hepatocytes and maintaining them in long-term culture with significant amplification in a two-dimensional (2D) environment. The team was led by Prof.
Researchers develop novel procedure for isolating primary mouse hepatocytes with holographic acoustic tweezersConstruction of functional primary hepatocytes culture model in vitro with holographic lattice-based acoustic tweezers. Credit: LI Fei, SIAT
Holographic acoustic tweezers exhibit significant potential in constructing in vitro 3D models for investigating the mechanisms of cancer, testing and selecting suitable anticancer drugs, and developing new medications. However, there is a lack of in-depth research on the biological effects of HAT on
Subsequently, they used the acoustic radiation force of the acoustic potential well to assemble cells into specific lattice patterns, simulating the anatomical structure of the liver. This work establishes the foundation for the development of an ex vivo model through acoustical holographic lattice techniques, carrying significant implications for future 3D tissue engineering applications.: Researchers develop novel procedure for isolating primary mouse hepatocytes with holographic acoustic tweezers retrieved 23 July 2024 from https://phys.org/news/2024-07-procedure-isolating-primary-mouse-hepatocytes.
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