Parkinson's Link to Gut Bacteria Hints at Unexpectedly Simple Treatment

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Parkinson's Link to Gut Bacteria Hints at Unexpectedly Simple Treatment
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Recent research adds further evidence to the link, identifying gut microbes likely to be involved and linking them with decreased "Supplementation therapy targeting riboflavin and biotin holds promise as a potential therapeutic avenue for alleviating Parkinson's symptoms and slowing disease progression,"Symptoms typically begin with constipation and sleep problems, up to 20 years before progressing into dementia and the debilitating loss of muscle control.

Analyzing fecal samples from 94 patients with Parkinson's disease and 73 relatively healthy controls in Japan, Nishiwaki and colleagues compared their results with data from China, Taiwan, Germany, and the US. While different groups of bacteria were involved in the different countries examined, they all influenced pathways that synthesize B vitamins in the body. "Deficiencies in polyamines and SCFAs could lead to thinning of the intestinal mucus layer, increasing intestinal permeability, both of which have been observed in Parkinson's disease," Nishiwaki They suspect the weakened protective layer exposes the intestinal nervous system to more of the toxins we now encounter more regularly.part of our brains – and increased nervous system inflammation, eventually leading to the more debilitating motor and dementia symptoms of Parkinson's.In Parkinson's disease, a reduction in the gut bacteria of genes responsible for synthesizing the essential B vitamins B2 and B7 was found. (: Gut microbes that naturally produce more methane are also able to squeeze more energy and calories out of high-fiber foods."We found that certain species of human gut bacteria have a remarkably high capacity to soak up PFAS from their environment at a range of concentrations, and store these in clumps inside their cells,"involved in Parkinson's disease, it's likely that not all patients experience the same causes, so each individual would need to be assessed. "Using these findings, we could identify individuals with specific deficiencies and administer oral riboflavin and biotin supplements to those with decreased levels, potentially creating an effective treatment."Big breakthroughs. Bold ideas. Straight to your inbox.

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