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Researchers evaluated"on-treatment weight loss" and the occurrence of gastrointestinal side effects in participants, who were either overweight or had obesity. According to findings, patients taking tirzepatide"were significantly more likely to achieve weight loss," and changes in weight were larger for patients on tirzepatide after three months, six months, and 12 months of treatment.
When looking at rates of GI adverse events, reports were similar for patients on both treatments. Researchers specifically looked at moderate to severe side effects such as bowel obstruction, cholecystitis , gallstones, intestinal infection, pancreatitis, and gastroparesis . Researchers did not evaluate the incidence of nausea and vomiting, which are classified as mild adverse events.Rates of treatment discontinuation were also similar. Within 12 months, 55.
For the study, patients who were on tirzepatide were taking 10 milligrams per week, while those taking semaglutide were taking 2.4 milligrams per week., Novo Nordisk pointed out"key limitations" of the study, specifically the inclusion of patients with type 2 diabetes , the lack of comparison to Wegovy , and"lacking data" about dose titration.
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