Some users taking weight-loss drugs say they are experiencing side effects that include a change in habits and moods, but not always for the better. NBC’s Vicky Nguyen reports for TODAY on what’s being dubbed “Ozempic personality.
Johann Hari still remembers the strange sensation he felt two days after he first injected himself with Ozempic. A doctor prescribed the drug for weight loss — a famous side effect of the Type 2 diabetes treatment — in 2023 when Hari weighed 203 pounds and had a body fat percentage of 32%. Hari’s grandfather died of a heart attack at 44, his uncle in his 60s, and his father underwent a quadruple heart bypass in his 70s.
You call these weight-loss drugs “a mass experiment, carried out on millions of people, and I am one of the guinea pigs.” Why? Hari: I’m part of two experiments, not just one. I was part of the experiment that made us so much more obese. And now I’m part of the experiment that’s reversing that using drugs. In my lifetime, we’ve had an explosion of obesity that’s unprecedented in human history.
What specifically bothered you? Hari: For myself, the one risk that I didn’t see coming was the psychological effect. That was really strange. For the first six months I was taking the drug, I was getting what I wanted — I was losing loads of weight, my back pain went away, all sorts of good things happened. But I didn’t actually feel better in my emotions. If anything, I felt slightly worse. I realized it was about my inability to comfort eat, and how bad that was making me feel.
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