Intermittent hypoxia caused by obstructive sleep apnea increased the susceptibility of mice to develop abdominal aortic aneurysms, researchers report in a new study.
Obstructive sleep apnea may be a risk factor for developing abdominal aortic aneurysms, according to researchers from the University of Missouri School of Medicine and NextGen Precision Health.
"Chronic intermittent hypoxia by itself is not enough to cause abdominal aortic aneurysms, but for a patient with obstructive sleep apnea who also has additional metabolic problems like obesity, our findings suggest it may help degrade aortic structures and promote aneurysm development," said Luis Martinez-Lemus, study author and a professor of medical pharmacology and physiology.
Luis Martinez-Lemus is a professor of medical pharmacology and physiology, the James O. Davis Distinguished Professorship in Cardiovascular Research, and a NextGen Precision Health investigator. He earned his PhD at Texas A&M University and is a Doctor of Veterinary Medicine. Neekun Sharma is an assistant research professor in the Division of Endocrinology and Metabolism in the Department of Medicine.
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