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production accelerates as mice refeed after fasting.
Intestinal stem cells are amongst the busiest in the body, constantly dividing and growing to reline the intestine every 5 to 10 days. This high level of activity also means cancer-causing aberrations are more likely – and that likelihood increases even further during the supercharged post-fasting period, the study shows., which the stem cells operate through.
These molecules are key to helping the body recover and regenerate after being deprived of the nutrients and energy supplied by a regular diet. However, the study demonstrates the probability of tumors rises as well, especially in conditions more favorable to cancer growth. "In the fasted state, the ability of cells to use lipids and fatty acids as an energy source enables them to survive when nutrients are low. And then it's the postfast refeeding state that really drives the regeneration."of anti-cancer therapies. Yet these studies have focussed largely on abstaining from food, without considering the potential consequences of breaking the fast.As is often the case in studies like these, animal models can only tell us so much.
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