Rams vs. 49ers? Jim Harbaugh vs. Mike Tomlin? Picks, predictions and stats for every Week 10 game.
will face off in what's expected to be an intriguing QB duel, and Detroit will seek revenge against the Commanders after losing to them in the 2024 playoffs. We have you covered with everything you need to know.
Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and anugget for each contest. Plus, analytics writer Aaron Schatz makes a bold prediction for each matchup, and fantasy analyst Eric Moody sharesLet's get into the full Week 10 slate, which culminates with a "Monday Night Football" matchup between the Eagles and Packers onAtlanta's defense has been mostly good this season, allowing the fourth-fewest yards per game in the league . But it has been vulnerable on the ground, ranked just 26th in expected points added per designed run . On Sunday in Berlin, the Falcons have to contend with, one of the NFL's best running backs, whom coach Raheem Morris referred to as someone "you need to bring a lot of people to tackle."concussion . If the Colts go this route, it frees up the rest of their secondary to handle the remaining matchups, including a notable one with tight end. had a career-high three passing touchdowns in the team's Week 9 loss; Penix has yet to have back-to-back games with multiple passing touchdowns in his career.The Colts will hold London under 50 receiving yards. The Colts have a wild split this season in which they rank first into 6 yards last week! It's schematic, not related to any specific cornerback, although it can't hurt to have Gardner arriving this week. The Colts' offense will look to get back on track. Atlanta's defense has allowed the sixth-fewest fantasy points per game to QBs, so expectations for the Indianapolis passing game should be modest. However, Taylor is positioned for a heavy workload behind a offensive line that ranks third in run block win rate . The Falcons' defense has also allowed the 10th-most rushing yards per game ., who scored two touchdowns in his last game, needs 18 yards to surpass Derrick Mason and become the franchise's all-time leader in receiving yards. He could be primed for another big game against a Vikings defense that has struggled to contain tight ends the past two weeks in the Chargers'. "I've really never felt better," Andrews said. "I'm running faster than I ever have. I'm moving better, and I feel great."has a 24-3 career record against NFC teams, but the Vikings have an experienced counterbalance. Defensive coordinator Brian Flores coached against Jackson twice when he was the Dolphins coach. In the second matchup, during the 2021 season, Flores blitzed Jackson on 52.1% of his dropbacks and held the Ravens' offense to 10 points. But that doesn't mean he'll choose the same path Sunday. In 2025, the Vikings' worst defensive games have come with their highest blitz rates.The Ravens have allowed only one passing touchdown over their past three games .The Vikings will blitz less than usual. Minnesota's defense blitzes 39% of the time, second in the league behind Atlanta, but Jackson is second with an 85.4 QBR against blitzes since the start of last season. Flores can switch things up to avoid Jackson's strength.has scored 11 or more fantasy points in two of his past three games. The Ravens' defense has improved significantly over their past three games in total yards allowed and points allowed, but it has still given up the second-most field goal attempts this season. As a result, Baltimore has allowed the seventh-most fantasy points per game to kickers.'s hamstring injury puts his status in doubt and could create a significant void as he has played more than any Patriots receiver this season while totaling 23 receptions for 431 yards and a team-high five touchdowns. Third-round draft pick could see his role expand as a result, with coach Mike Vrabel saying, "Kyle's been learning a lot of different positions; it's a lot of different personnel groups and alignments. I think he settled down. I'm excited that he'll probably get an opportunity here.": "I didn't think he was going to be as good." But Tristin had been with the Eagles, and they had a joint practice against the Patriots. "He goes, 'Nah, we played him. He's special. He's a sleeper dual-threat quarterback," recalled Zyon, who eventually took a closer look at the film and reached a similar conclusion. "He's really, really impressive. He throws the deep ball better than a lot of guys in this league, and he's very composed and he can run, so he'll be a great challenge for us."The Patriots have not allowed an opposing running back to reach 50 rushing yards; they are the only team to do so through the first nine games since 1950.is currently 56th among qualifying tackles with a pass block win rate of 83.8%, while taking sacks is Maye's biggest weakness . Only the Titans' Maye remains firmly on the QB1 radar, even against a tough Bucs defense that has allowed just 16.6 fantasy points per game to QBs. However, Tampa Bay has also given up the fifth-most rushing yards per game to the position, which boosts Maye's upside. It's still difficult to trust any of the Patriots' pass catchers in fantasy lineups, as Maye has spread targets evenly across the group.will look to continue his historic commanding performances against the Dolphins. In 15 games with Allen starting against Miami, the Bills have averaged 32.5 points per game, the fifth-highest team mark by a starting QB against a single opponent in the Super Bowl Era . This is also a prime game for Allen to score another rushing touchdowns as Miami has allowed four rushing touchdowns to QBs, second most in the league.took responsibility for his play this season -- which he said falls well below the standard he has set in previous seasons -- but he stopped short of saying he's playing for his job when asked. Coach Mike McDaniel said earlier this week that the team is "certain" Tagovailoa is the best option against the Bills, but he left things relatively open-ended after this week: "We play the players that give us the best chance to win and when that changes or if that changes or if somebody else gives us a better shot, then we adjust there.". With another pick, Tagovailoa would be first Dolphins QB since Chad Henne in 2010 with 12 or more interceptions in his first 10 games of a season.from picking up long gains in the passing game. Buffalo is second in DVOA against running backs as receivers, and it kept Achane to just 29 yards on seven catches when these teams met inhas averaged 16.0 fantasy points in the four games this season in which he has seen at least six targets. Even though he splits snaps with two other TEs , Kincaid leads the group in routes run, which is what matters most for fantasy production. He's in an excellent spot against a defense that allows the fifth-most fantasy points per game to TEs.The Texans surprised the Jaguars in their first meeting by extensively using a defensive look that coach Liam Coen said Houston had used only situationally the past two seasons, and it stymied Jacksonville's run game.. had just 5 yards on four carries in the first half until the Jaguars adjusted in the second. Jacksonville expects to see some of that again, plus a few other wrinkles from coach DeMeco Ryans. "It's a damn good defense, and they don't stay blocked long," Coen said. "We have got to go finish at the second level, stay attached to blocks, run through contact, block our asses off on the perimeter. That's how it's going to have to be, man."will get the nod. Mills has a record of 5-19-1 when he was a Texan starter in 2021-2022. Coach DeMeco Ryans said Mills getting a full week of practice should only help himself instead of jumping into the fire midgame like last week. "It is a benefit for him, being able to get the reps throughout practice, get walk-through , getting every single rep that he can get," Ryans said. "He's done a good job with that."will record his first receiving touchdown of the season. Jacksonville is 25th in DVOA against tight ends and allows an opponent-adjusted 78 yards per game to the position, 31st in the league. Plus, backup QBs tend to love their tight end security blankets. Quarterbacks have averaged the fewest fantasy points per game against Houston , and receivers have averaged the second fewest . Houston is one of the rare defenses that fantasy managers can comfortably hold for the entire season. On the other side of the matchup, managers looking for a TE streamer should consider Schultz, as the Jaguars allow the second-most fantasy points per game to the position.The Giants haven't been able to stop the run this season -- really, for the past four seasons. They're allowing an NFL-worst 5.5 yards per carry and have allowed over 30 points in three straight games. It's not going to get any easier against the Bears' second-ranked rushing offense. Where are the answers for the defense? "We're working, putting our head down, and hopefully we can get some better results here going forward," coordinator Shane Bowen said. It might take more than that this week to stop Chicago from running the ball.Special teams issues piled up in Week 9: Chicago's opening kickoff was returned for a touchdown by the Bengals'missed a field goal and had another blocked; and the execution on a late onside kick allowed the Bengals to score two touchdowns in 49 seconds. Coach Ben Johnson said Chicago's special teams units were "too passive at times," while coordinator Richard Hightower vowed to make sure the litany of blunders doesn't happen again. "We're going to work night and day to get it all cleaned up," Hightower said. "I can promise you that I will bust my ass and they will, too, all right, to get it cleaned up."had career highs in receiving yards and touchdowns last week. He is looking to become the third rookie in franchise history with 100 or more receiving yards in consecutive games .Consistent runs of 5-10 yards will keep Chicago moving the sticks. The Bears are first in the league in second-level yards per carry . The Giants' defense is last in second-level yards per play.is an exciting player to roster in fantasy leagues, thanks to his dual-threat ability. He has scored 19 or more fantasy points in five of his past six games, giving him both a strong floor and ceiling. The Bears' defense has been a fantasy bonanza for opposing QBs, allowing the seventh-most fantasy points per game to the position. Dart, running backin the preseason, he has not been a big part of the offense and has been targeted only 10 times with five catches. Vele is part of the effort to get some of the new and young players snaps, with rookie QBsaid about playing the one-win Saints. New Orleans ranks among the league's worst offenses in almost every category, but, as Evero reminds, the Saints still have some "formidable pieces'' and his defense can't take them lightly.A lack of pressure will give Shough a chance to finally establish himself as the Saints' starter. Carolina ranks 28th in pass rush win rate and 31st in pressure rate . Shough is 30-of-44 passing without pressure but 2-of-12 when pressured.back in the mix. He has had four games with at least 18 touches, and he has averaged 26.2 fantasy points in those contests. He draws a favorable matchup against a defense that has allowed the ninth-most rushing yards per game . The Panthers' offensive line also ranks 12th in run block win rate , which further supports his outlook.Coming out of the bye, the Browns are making a change at playcaller as coach Kevin Stefanski is relinquishing the duties to coordinator Tommy Rees. The playbook will remain the same, but Rees will have final say on which plays go into the game plan as he gets his opportunity to turn around the league's third-lowest-scoring offense . "His mindset and the way he wants to call plays and stuff like that, we're kind of excited to see what happens," left guardThe Jets are coming off a bye, which usually means disaster. In their past nine games after a bye, they're 1-8 with a minus-108 point differential. Can coach Aaron Glenn bust the trend? The locker room was rocked by the trades of cornerback, so it'll be interesting to see what kind of effort Glenn gets from his players. Offering the coaching perspective, defensive coordinator Steve Wilks said, "They're not canceling the damn season."over the middle of the field. Gabriel throws over the middle on 29% of his passes, the highest rate in the NFL. But New York ranks ninth in DVOA on passes over the middle .draws a favorable matchup against a defense now without Williams. New York has allowed the seventh-most rushing yards per game to RBs, and with the Jets appearing to be in rebuild mode, Judkins and the Cleveland offensive line should be able to take advantage. Judkins has had four games with at least 15 touches, and he has averaged 19.5 fantasy points in those contests.The Browns are 0-4 ATS on the road this season, and they are 0-4 ATS in their past four games as underdogs.'s for the next four weeks -- and that's a good thing for Arizona. It has averaged more than 300 total yards and 25 points in Brissett's three starts thus far, which has resulted in a 1-2 record. He has been around long enough -- 10 seasons, to be exact -- to not let the uncertainty from week to week affect him. "It doesn't really change much for me. The cliché answer is you prepare every week like you're starting, but it's honestly true," Brissett said. "It won't change much about my preparation and how I go about my business."The Seahawks will see a much different Arizona offense than the one they held to 20 points and 253 total yards in. Arizona has since switched from Murray to Brissett. "They're putting up points, they're playing efficiently, they're taking care of the ball, they're doing a lot of really good things," coach Mike Macdonald said. "They were doing that before, but how they got it done was a little different with Jacoby a little more under center. They've eliminated some of the quarterback-driven run game that Kyler brings. There's some differences in how they're operating, but I'd say it's been effective."'s 273 career receptions are the second most by a tight end in their first four seasons in NFL history, behindThe Seahawks will have a significant lead at halftime. Seattle ranks first in offensive DVOA in the first quarter as well as the first half. Arizona is last in offensive DVOA in the first quarter and 25th in the first half.can be frustrating for fantasy managers, because both are actively involved, the duo is in a good spot this week. Seattle's offensive line ranks ninth in run block win rate , and the team ranks eighth in rushing attempts per game. Both Walker and Charbonnet should be considered flex options., San Francisco won on a field goal in overtime. According to ESPN Research, it was the eighth game, including the playoffs, between coaches Sean McVay and Kyle Shanahan decided by three or fewer points, which is tied for the third most for any NFL coaching matchup in NFL history. "We know that it's going to take 60 minutes and then maybe even then some," McVay said.At 3-0 in NFC West games, the 49ers have a big opportunity to cement potential tiebreaker situations over the next couple of weeks, starting Sunday. The Niners are well aware that Los Angeles enters this game upset after losing in Week 5, which is why running backsaid his focus is on making sure everyone is locked in. "This one's obviously big," McCaffrey said. "The intensity and the urgency have to be there all week, and the preparation, so we can come out and execute at a high level on Sunday."McCaffrey has 100 scrimmage yards in eight of nine games this season, two more than any other player in the NFL.' success in the middle of the field. Jones actually leads all QBs in passing value to the middle of the field based on myhas emerged as a viable fantasy starter in an offense that ranks seventh in total yards and sixth in points per game . He has scored 25 or more fantasy points in four of his past five games, and he's in a strong spot this week with WRsactive. The 49ers' defense has allowed 17.7 fantasy points per game to opposing QBs, giving Stafford a high floor and clear upside.at home in last season's divisional round, Detroit will be out for revenge. But the Lions are still looking to find an offensive identity under first-year coordinator John Morton entering the rematch. "So far, the frustrating part is that we are explosive, but inefficient," passing game coordinator David Shaw said. "We're never out of a game. The guys that we have, we're one play away from scoring a touchdown no matter where we stand for ball. That remains to be true."Washington continues to tinker with its defense in hopes of salvaging the season. It "pared down" some of its calls two weeks ago, but the Commanders still allowed a combined 66 points the past two games. Now, defensive coordinator Joe Whitt Jr. will call plays from the field rather than the coaches booth. He said it was his idea after some players prodded him to do so, wanting more energy on the sideline and better communication during games. Washington is tied for the most pass plays allowed of at least 20 yards. Now they must somehow stop the NFL's second-highest-scoring offenseThe Commanders have three straight losses by 20-plus points, one loss shy of matching the longest such streak in franchise history.are in great spots against a defense that has allowed the third-most fantasy points per game to QBs. Seahawks'-led offense that ranks sixth with 250.6 passing yards per game. The Steelers will get a boost by having a full week of work fromat the safety spots. "The more subtle things, the intangible things I think are the things that are exciting for us because as gains more experience back there, it's reasonable to expect some of those talents to show up more frequently," coach Mike Tomlin said.The Chargers have been derailed by injuries and are down to their fourth- and fifth-string running backs and backup left tackles. Los Angeleswith hopes that he can help keep this season afloat. "He's tough," coach Jim Harbaugh said. "He's kind of like what we like and fits in great with the room."The Steelers will run on most first downs with their heavy personnel. Pittsburgh is 12th in DVOA when running the ball on first downs, but 27th when passing. Meanwhile, the Chargers are last in defensive DVOA against the run on first downs.has a strong opportunity to deliver a week-winning performance. He has seen at least five targets in four straight games and scored 11-plus fantasy points in each, with two games of 18-plus. Pittsburgh has allowed the third-most fantasy points per game to TEs, and its defense ranks third in pass rush win rate . Meanwhile, the Chargers' offensive line ranks 29th in pass block win rate . That mismatch could lead Herbert to rely on Gadsden as a safety valve.as "disruptive" and said he plays the position exactly how they like against both the run and pass. The Eagles enter this matchup tied for 25th in sacks . Phillips can give that pass rush a boost along with the potential return ofthis week after the Packers sponsored the failed rule change proposal attempting to ban the play this offseason, but he knows it's coming. "The NFL made a decision, and we have to find a way to try to stop the play and it's a tough play to stop," LaFleur said. "The best way to stop it is to not to allow it to happen. ... You can't allow them in those short-yardage situations because you know exactly what they're going to do, and they've been pretty successful at it, obviously."The Eagles' three turnovers this season are the fewest in the NFL and tied for their fewest through eight games all time.has only 39 targets, but he has still scored at least 10 fantasy points in six of seven games, including three games with 17 or more, thanks in part to his league-leading seven touchdowns as a TE. He has a favorable matchup this week against a defense that allows the seventh-most fantasy points per game to the position.
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