New analysis of the REDUCE-IT trial suggested benefit of icosapent ethyl doesn't vary by Lp(a) level and confirmed risk for Lp(a) with high triglycerides but not cholesterol.
Baseline lipoprotein a, or Lp, levels are strongly associated with major adverse cardiovascular events in high-risk patients with elevated triglyceride levels receiving statin therapy, a new analysis suggested., Amarin), a refined version of omega-3 fatty acid eicosapentaenoic acid , was associated with a reduction in this risk across a range of Lp levels.
This new analysis included 7026 patients from REDUCE-IT, mean age about 64 years, who had baseline Lp assessments. The median baseline concentration was 11.6 mg/dL. The study showed the treatment effect of IPE is consistent across different Lp concentrations. "Whether your baseline Lp is low or high, the treatment has a benefit in terms of MACE," said Szarek.
They noted that while reduced CV risk associated with IPE is consistent across Lp levels, the absolute event rates remained relatively high in those with Lp ≥ 50 mg/dL compared with those with Lp < 50 mg/dL.
Lipid Management CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Interprofessional Interprofessional Collaboration Interprofessional Team Health Care Team Team-Based Care Teamwork Collaborative Practice Interprofessional Education Interprofessional Continuing Education Interprofessional Practice IPCE IPE Triglycerides
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