The triple-acting drug was found to lower blood sugar and weight in people with diabetes.
, Eli Lilly reported the first late-stage results of its experimental drug retatrutide, which targets three weight-related hormones: GLP-1, GIP, and glucagon. Adding glucagon led to greaterin a group of more than 530 people recently diagnosed with diabetes who were randomly assigned to one of three doses of retatrutide, compared to placebo.
People who took the highest dose of retatrutide lowered their A1C, a measure of blood sugar, by up to 2%—similar to Mounjaro—and helped people to lose an average of 16.8% of their starting weight over the 40-week study period. Those who took placebo lowered their A1C by 0.8% and lost an average of 2.5% of their weight. Lilly’s studies of Mounjaro and Zepbound show that they help people taking them to lose anywhere from 15% to 20% of their body mass. “For patients with diabetes, a population that has historically struggled to lose weight and could be seeking a greater level of weight loss, this data suggests retatrutide could be a strong option,” says Kenneth Custer, president of Lilly cardiometabolic health.by lowering cholesterol, triglycerides, and blood pressure. Adding another target did not substantially increase the side effects of the drugs, which are similar to those for other GLP-1-based drugs, and include gastrointestinal discomfort, diarrhea, and nausea. The data are just the first on the drug, and Lilly is also studying it for obesity, osteoarthritis, and other indications. Those results are expected later this year. Custer says that potentially adding drugs like retatrutide to the list of medications available for people with diabetes, obesity, or both is important since different patients will need to lower their blood sugar or weight by different amounts over varying periods of time.The People the Clean Energy Transition Is Leaving Behind A New Hydropower Deal Will Provide Clean Energy to NYC. Here's How a Canadian First Nation Made It Happen
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