A team developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip -- OPTECs-on-Chip -- that mimics in vivo renal physiology more closely than ever before. This model exhibits enhanced expression and polarity of essential renal transporters, making it a powerful tool for assessing drug transport and nephrotoxicity.
Developing advanced drug screening tools is crucial for the advancement of personalized medicine and the creation of more effective treatments. One organ receiving particular attention in this area is the kidney.renal physiology more closely than ever before. This model exhibits enhanced expression and polarity of essential renal transporters, making it a powerful tool for assessing drug transport and nephrotoxicity.
"We demonstrated that our OPTECs-on-Chip not only assesses nephrotoxicity but also quantifies transcellular substrates transported specifically by OAT1, OAT3, and OCT2. This highlights the benefits of using iPS cell-derived cells and a microfluidic system to replicatecellular transport mechanisms," add co-author Minoru Takasato at the RIKEN Center for Biosystems Dynamics Research, together with Toshikazu Araoka of KyotoU's Center for iPS Cell Research and Application.
"Our model has significant potential for drug screening and personalized medicine," notes Yokokawa."By incorporating patient-derived stem cells, we can develop personalized assessments for renal transport and disease modeling." A research team has successfully developed a biomimetic chip that combines organoid and organ-on-a-chip technologies to simulate the complex defense mechanisms of the human gastric ...
Personalized Medicine Stem Cells Medical Topics Computer Modeling Mathematical Modeling Computer Science Mobile Computing
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