Scientists are now able to directly compare the different kinds of injury that mechanical ventilation causes to cells in the lungs. In a new study, using a ventilator-on-a-chip model, researchers found that shear stress from the collapse and reopening of the air sacs is the most injurious type of damage.
For the first time, scientists are able to directly compare the different kinds of injury that mechanical ventilation causes to cells in the lungs.
"The initial damage is purely physical, but the processes after that are biological in nature -- and what we're doing with this device is coupling the two," Ghadiali said. Of particular value is the ventilator-on-a chip's measurement of real-time changes to cells that affect the integrity of that barrier, enabled by an innovative approach: growing human lung cells on a synthetic nanofiber membrane mimicking the complex lung matrix. It's closer to the authentic ventilated lung microenvironment than any similar lung chip systems to date, the researchers say.
Englert said the collapse and reopening may be more problematic because it makes fluid in the lungs move, exposing cells to high amounts of shear stress. "We're in the early stages of developing some of those models, diving a little bit deeper into the complexity of lung injury in ICU patients," Englert said."This model is a platform we can build upon."
Lung Cancer COPD Developmental Biology Biotechnology And Bioengineering Biology Microarrays Thermodynamics Civil Engineering
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