Emapalumab-containing regimens showed positive outcomes in patients with rheumatologic disease–associated hemophagocytic lymphohistiocytosis, a rare and life-threatening disorder.
Emapalumab -containing regimens stabilize key laboratory parameters and show a high 12-month survival probability in patients with rheumatologic disease–associated hemophagocytic lymphohistiocytosis .Researchers conducted a retrospective medical chart review study across 33 US hospitals to assess the real-world treatment patterns and outcomes in patients with HLH treated with emapalumab.
Most patients with rheumatologic disease–associated HLH had either systemic juvenile idiopathic arthritis or adult-onset Still's disease . The primary objective of this study was to describe emapalumab treatment patterns such as time to initiation, treatment duration, dosing patterns, and reasons for initiation.Most patients with rheumatologic disease–associated HLH were critically ill and were initiated on emapalumab in an intensive care unit; emapalumab was mostly initiated for treating refractory and recurrent disease.
Emapalumab treatment led to achievement of normal fibrinogen levels , according to defined laboratory criteria in all patients with rheumatologic disease–associated HLH, and an 80.6% reduction in the required glucocorticoid dose.
Juvenile Ra Juvenile Idiopathic Arthritis Rheumatoid Arthritis RA - Rheumatoid Arthritis Rheumatoid Arthritis (RA) Disease-Modifying Antirheumatic Drugs Dmards DMARD Cytokines Lymphohistiocytosis Arthritis Joint Inflammation Glucocorticosteroids Glucocorticoid Therapy Glucocorticoid Refractory Healthcare And Medical Technology Health And Medical Tech
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