New research reveals how dying cells inadvertently release vesicles containing a protein that can damage healthy cells, fueling the inflammation that characterizes sepsis.
Dying cells, in an effort to protect themselves and their neighbors from harmful infections, can inadvertently unleash a lethal message that worsens sepsis. This process, detailed in a recent study published in , involves the release of gasdermin-D vesicles by dying cells. These vesicles contain a protein, gasdermin-D, that forms pores in the membranes of healthy cells, causing them to die. This chain reaction of cell death fuels the runaway inflammation characteristic of sepsis.
\Sepsis, a life-threatening condition, claims 11 million lives globally each year, making it one of the leading causes of death worldwide. While infections often trigger sepsis, research indicates that the primary driver of the devastating inflammation is the response of the body's own cells, even those not directly infected. When cells sense a threat, they activate a self-destruction mechanism, releasing gasdermin-D to create pores in their membranes. This process often results in cell death and the formation of gasdermin-D-containing vesicles. \These vesicles can then travel to nearby healthy cells and inject the gasdermin-D pores, leading to further cell death and the propagation of the inflammatory cascade. This vicious cycle can overwhelm the body's defenses, resulting in organ failure and death. The discovery sheds light on a critical aspect of sepsis pathogenesis and opens new avenues for therapeutic intervention. Researchers are now investigating strategies to block the release or activity of gasdermin-D vesicles, aiming to interrupt this deadly chain reaction and potentially develop effective treatments for sepsis and other inflammatory diseases
SEPSIS INFLAMMATION CELL DEATH GASDERMIN-D VESICLES TREATMENT
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