Hormone-modulating therapy for breast cancer was associated with a reduced risk for dementia in some older women, according to a large retrospective study.
Hormone-modulating therapy for breast cancer may protect older women from Alzheimer's disease and related dementias, although the protective effect varies by age and race, with the greatest benefit seen in younger Black women.Hormone-modulating therapy is widely used to treat hormone receptor–positive breast cancer , but the cognitive effects of the treatment, including a potential link to dementia, remain unclear.
The researchers excluded women with preexisting Alzheimer's disease/dementia diagnoses or those who had received hormone-modulating therapy before their breast cancer diagnosis. Overall, hormone-modulating therapy use was associated with a significant 7% lower risk for Alzheimer's disease/dementia , but that protective effect decreased to 19% in Black women aged 75 years or older . White women aged 65-74 years who received hormone-modulating therapy had an 11% lower risk for Alzheimer's disease/dementia , but the association disappeared among those aged 75 years or older .
Malignant Breast Neoplasm Breast Carcinoma Breast Mammary Gland Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Dementia Alzheimer's Disease Alzheimer Disease Genomics Genomic Medicine Hormone Therapy Hormonal Therapy Receptors South Carolina Aromatase Inhibitor Exemestane Chemotherapy Estrogen Estrogen Therapy Genetics Medicare Surgery
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