Hormone modulating therapy (HMT) used for the treatment of breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias later in life, according to a new study.
Hormone modulating therapy used for the treatment of breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias later in life, according to a new study.
To improve understanding about the risk of ADRD following HMT in breast cancer patients, Modugno, teamed up with lead author Chao Cai, Ph.D., assistant professor at the University of South Carolina College of Pharmacy. They used a federal database of people aged 65 and older to identify women who were diagnosed with breast cancer between 2007 and 2009 and who did not have a previous ADRD diagnosis or history of using HMT before their breast cancer diagnosis.
Black women aged 65 through 74 who used HMT had a 24% reduction in relative risk of developing ADRD, which dropped to 19% after age 75. White women aged 65 through 74 had an 11% reduction in risk of ADRD with HMT use, but this beneficial association disappeared after age 75. According to Cai, estrogen has neuroprotective effects, so these therapies could influence ADRD risk by mimicking estrogen, influencing estrogen production or modulating estrogen receptor levels. HMT might also affect clearance of a protein called beta-amyloid, stability of tau protein and vascular health, all of which are closely linked to brain health and ADRD risk.
Cancer Women's Health Diseases And Conditions Alzheimer's Dementia Multiple Sclerosis Disorders And Syndromes
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