Baseline bone pain was associated with worse survival outcomes in patients with metastatic hormone-sensitive prostate cancer, according to a recent post hoc analysis.
and baseline bone pain at diagnosis have worse overall survival compared to those without bone pain, a post hoc study found.Prostate cancer often metastasizes to the bones, leading to pain and a reduced quality of life. While the relationship between bone pain and overall survival in metastatic, castration-resistant prostate cancer is well-documented, its impact in metastatic hormone-sensitive prostate cancer is less clear.
Researchers conducted a post hoc secondary analysis using data from the SWOG-1216 phase 3 randomized clinical trial, which included 1279 men diagnosed with metastatic hormone-sensitive prostate cancer from 248 centers across the United States. Patients had received androgen deprivation therapy either with orteronel or
Among the 1197 patients with data on bone pain included in the secondary analysis, 301 reported bone pain at baseline.The median overall survival for patients with baseline bone pain was 3.9 years compared with not reached for those without bone pain at a median follow-up of 4 years . Several authors declared ties with various sources.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Malignant Prostate Neoplasm Prostate Cancer Cancer Of The Prostate Pain Management Bones Pain Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Prostatic Biologic Therapy Biologics Prostate Specific Antigen PSA- Prostate Specific Antigen Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology
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