Research on the role that genes play in psoriasis has led to targeted therapies to reduce symptoms and slow disease progression.
. Cytokines, including interleukin -17, IL-22, IL-23, and tumor necrosis factor alpha, are associated with an increased risk for psoriasis. These cytokines lead to persistent inflammation, leading tokeratinocyte proliferation, which causes the skin manifestations characteristic of psoriasis. However, the exact cause of this disruption is still not clear.of psoriasis is complex, with genetic, immunologic, and environmental factors thought to play a key role in disease development.
Indeed, studies have reported that monozygotic have amajor histocompatibility complexhave further identified that the HLA-Cw6 allele plays a key role in the pathogenesis of psoriasis by binding to one or more psoriasis autoantigens. signal transduction. The NF-kappa B pathway encodes several genes involved in intracellular signaling and is one of thegenetic markers.
Psoriasis Psoriatic Arthritis Arthropathic Psoriasis Psoriatic Arthropathy Psa Cytokines Genetics T Cell Lymphocytes Plaque Psoriasis Fellowship Fellows Residency Residents Antigens Receptors TNF-Alpha Tumor Necrosis Factor-Alpha TNF Alpha Cachexin Cachectin Biologic Therapy Biologics Genomics Genomic Medicine Antiviral Famciclovir Valacyclovir Arthritis
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