Analysis of thousands of tumors shows that inherited genes determine how a breast tumor develops from its earliest stages.
A colored magnetic resonance imaging scan shows a cancerous tumor in a woman's breast. New research shows cancer cells can give earlier indications about the ultimate severity of the disease.A woman’s inherited genes are a powerful indicator of what kind of breast cancer she might develop, a recent study reveals.
“If we can understand which mutations are driving the development of these more aggressive tumors, it will be extremely helpful for predicting which patients are going to suffer more from their disease,” says Michalina Janiszewska, a cancer biologist at the University of Florida Scripps Institute.A gene mutation causing cells to go rogue isn’t as rare as you might think, says Kornelia Polyak, a molecular biologist at the Dana-Farber Cancer Institute in Boston.
More than a decade ago, scientists believed that most cancer was something that happened over the course of a lifetime. The thought was that healthy cells produce cancerous ones randomly, and whether the cancer turned invasive and deadly was also up to chance—and it was impossible to pass on to children., Curtis found that even at their earliest stages, aggressive, metastatic colorectal tumors looked different on a cellular level than their more indolent counterparts.
This type of investigation required lots of data, so Houlihan and Curtis stitched together information from a range of datasets, including tumor cell atlases and cancer registries. Their analysis of over 6,000 breast tumors showed that cells varied in what scientists call their “germline epitope burden,” which could help predict how aggressive a cancer might form.
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