AI's Drug Revolution, Part 2: New Uses for Old Drugs

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AI's Drug Revolution, Part 2: New Uses for Old Drugs
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Hoping to skirt the slow pace of new drug development, researchers are leaning on AI to uncover fresh uses for known chemicals and already-approved treatments.

This is the second in a three-part series from Medscape Medical News on the impact of artificial intelligence on drug discovery and development.reports on AI's ability to create new proteins from scratch, streamlining the creation of protein-based therapeutics.

"Clinical trials with patient selection markers will dramatically improve success by up to 90%," Jun said. Available drugs only treat symptoms of CCM, such as seizures and bleeding in the brain. Cell imaging pointed to the effectiveness of a small molecule known as a superoxide scavenger. The researchers were surprised, but when they foundFor the approximately 350,000 people with CCM, a new treatment could become available soon. The finding may also have implications beyond CCM, which causes leaky blood vessels, a symptom seen in many other diseases, including multiple sclerosis and sepsis.

If compounds are well understood or have FDA approval for other indications, their toxicity and possible side effects have been assessed. Knowing that a drug can be safely administered to healthy patients"can save you the phase 1 trials," said Owen."Potentially, you can get into phase 2 trials, depending on the disease model evidence that you have."

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