Abnormalities in neurodevelopment could lay the foundations for Alzheimer'sdisease InstitutCerveau ScienceAdvances
—begins in the fetus from five weeks gestation and is almost complete by 28 weeks. It is a complex process with finely tuned mechanisms."In humans, neurogenesis lasts particularly long compared with other species," explains Khadijeh Shabani, a post-doctoral researcher at Paris Brain Institute."Neural stem cells remain in a progenitor state for an extended period.
In many species, APP is involved in various biological processes, such as repairing cerebral lesions, orchestrating cellular response after oxygen deprivation, or controlling brain plasticity. It is highly expressed during the differentiation and migration of cortical neurons, suggesting an essential role in neurogenesis. But what about humans?
"This comparison provided us with valuable data," Shabani explains."We observed that in the absence of APP,produced many more neurons, more rapidly, and were less inclined to proliferate in the progenitor cell state." Specifically, the team showed that APP was involved in two fined-tuned genetic mechanisms: on the one hand, canonical WNT signaling, which controls stem cell proliferation, and AP-1 activation, which triggers the production of new neurons.
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