Significant correlation found between vitreous human biomarkers and Alzheimer'sdisease The_BMC IOSPress_STM
]. This study did not find an association of vitreous NfL with the neuropathological diagnosis, but it was associated with CTE staging, consistent with prior studies in CSF. We saw statistically significant increase in NfL in low stage CTE versus controls as well as versus high stage CTE, which was retained on further adjustment for multiple comparisons. Further larger sample sized studies could be helpful to elucidate its role as a biomarker for CTE staging.
The potential utility of procuring eye fluid for immunoassay analyses, as a diagnostic marker for AD or CTE, is still being explored. Compared to CSF analysis, a sampling eye fluid may be potentially safer, quicker, and more accessible to obtain with a potentially less risk of adverse events. It may be done as an outpatient office procedure via aspiration with a needle tap and, depending on the type of eye fluid, it may not require surgical tools such as a mechanized biopsy with a vitrector.
There were limitations to our study. First, we had a small sample size due to the reliance on donation of post-mortem brain and ocular tissue samples for our study methodology. Given this limitation, subdividing the samples into pathologic groups resulted in several mixed cases of both AD and CTE and the overlap in the pathology of these diseases could be potentially confounding. Future studies with larger numbers will also allow for consideration of vascular and white matter pathologies.
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