Gut microbiota holds clues to predicting Alzheimer's risk gutmicrobiome Alzheimers preclinicalAD ADpathology ADriskmarkers neurodegeneration biomarkers gutbrainconnection etiology ScienceTM
By Dr. Sanchari Sinha Dutta, Ph.D.Jun 15 2023 Scientists at Washington University in St. Louis have identified specific alterations in gut microbiota composition related to preclinical neuropathology of Alzheimer’s disease. The findings might help identify novel gut-derived biomarkers to predict the disease risk.Study: Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease.
In the current study, scientists have examined cognitively normal individuals with and without preclinical AD to determine whether changes in gut microbiota can predict AD risk. Related StoriesThe comparison of gut microbiota characteristics between the groups was conducted after adjusting for dietary intake and several clinical covariates, including age, body mass index , apolipoprotein ε4 carrier status , diabetes, and hypertension.
However, no such association was observed for neurodegenerative markers. This could be explained by the fact that neurodegeneration occurs later in the clinical course of AD and that Aβ plaques and tau proteins are the early biomarkers to detect preclinical AD.
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