San Francisco 49ers running back Isaac Guerendo is expected to miss extended time after tearing his pectoral muscle during an offseason workout.
49ers coach Kyle Shanahan speaks to reporters following San Francisco’s first week of OTAs on Thursday in Santa Clara.tore his pectoral muscle while lifting weights and will miss most of the offseason program Kyle Shanahan shared on Thursday.
The 49ers opened up their second practice of Organized Team Activities to media and it quickly was noticed that the third-year ball carrier was absent from the field.
“Guerendo tore his pec lifting about a month ago,” Shanahan said. “It’s not a season-ender, but it’s right around the end of training camp. ”, starting his NFL career in 2024 appearing in 16 games — three as a starter. The Louisville product registered 84 carries for 420 yards and four touchdowns before not playing a single offensive snap in 2025.
To add depth to the running backs room, the club signed two ball carriers —Jermar Jefferson and Jordan Mims to one-year deals and waived Sincere McCormick. Withtaking the day off, both Jordan James and rookie Kaelon Black saw quite a few reps in team drills.
“I’m always curious how these guys are going to come back,” Shanahan said of James, who is entering his second season with the 49ers. “It was really cool, he came back in shape on Day 1 which I think has really allowed him to gain ground in these five weeks. “He didn’t come here for us to get him in shape, he came in shape and that allows him to get better at football.
” McCaffrey, who has been no stranger to injuries that have kept him from playing the game, shared that Guerendo has been upbeat in his rehab and is looking forward to a return to the field.
“Sometimes this game is super unfortunate,” McCaffrey said. “He was working his butt off all offseason and sometimes it’s that freak stuff that happens, when you strain something in the weight room when you’re training. “It’s unfortunate but got the best attitude, coming in every single day with a smile. Still working just as hard.
It’s not a season-ending injury. He’ll be back. It’s also perspective. As much as he’s down, he will back for the season, so I think there’s some enthusiasm there. ”
Isaac Guerendo Jennifer Lee Chan Kyle Shanahan
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