Good news: Scientists may be closer to a new way to treat arthritis.
Three research teams are working on new methods, mainly focused on kneeTwo teams — one at Duke University and another at University of Colorado Boulder — are developing injections or infusions that may help rebuild cartilage and bone.
A third team at Columbia University is working on a more revolutionary idea: regrowing an entire knee using a 3D-printed “scaffolding” filled with bone and cartilage cells,So far, these methods have only been tested in small animals. Results of animal studies often differ in humans.One method uses a drug that slowly releases in the joint and helps tissue repair itself over a certain amount of time. Another method uses proteins that fill in damaged areas and trigger the body to regrow cartilage in spaces where it should be. “It's hugely promising,” Dr. Scott Rodeo, vice chair of orthopedic research at the Hospital for Special Surgery in New York City, told. He was not involved with the studies.by regrowing cartilage and bone “would be a paradigm shift.”Researchers are testing ways to help the body's own cells grow again. “I tend to be very skeptical, but this surprised me,” Dr. Benjamin Alman, a pediatric orthopedic surgeon, toldSome treatments target cartilage, while others focus on remodeling bone or treating multiple joints at once. Teams funded by ARPA-H are required to begin testing in patients within 18 months,The agency has invested tens of millions of dollars in the work, including more than $42 million for one team alone. “For academic research, this is like pie-in-the-sky money,” Nadeen Chahine, a leader on the Columbia University team, added. If the treatments work, they must eventually be made available to patients and priced at no more than 25% of current treatment costs.
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