A systematic review found that switching from an originator product to a biosimilar did not significantly change the proportion of IBD patients in clinical remission. Other outcomes were similar between biosimilar and originator therapy. The results differ from a previous study and the Canadian Association of Gastroenterology and Crohn's recommended limiting biosimilar induction to previously untreated patients.
In a systematic review of real-world observational studies , it was found that the proportion of patients with IBD in clinical remission did not change significantly after switching from an originator product to a biosimilar. Other outcomes, such as loss of response and treatment cessation, were similar between patients who switched to a biosimilar and those who continued the originator therapy . The results differ from a previous study published in 2019.
The Canadian Association of Gastroenterology and Crohn's recommended limiting biosimilar induction to previously untreated patients
Biosimilar IBD Clinical Remission Originator Therapy Observational Studies
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