What time the malaria-bearing mosquito bites you might make a difference

Malaria News

What time the malaria-bearing mosquito bites you might make a difference
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Circadian rhythms appear to influence vulnerability to malaria parasites.

A discovery by McGill-affiliated researchers could lead to more effective treatment of malaria and other parasitic diseases.

Malaria is a mosquito-borne infectious disease that affects hundreds of millions of people worldwide. It kills more than half a million people each year, most of them children. Cerebral malaria is the deadliest form of the disease. "We explored how the circadian rhythms of both the host and the malaria parasite interact to affect the severity of the disease and the host's ability to fight off the parasite," said Priscilla Carvalho Cabral, a recent McGill PhD graduate who carried out the experiments described in two recent studies on the subject.

"Our results represent an important advance in knowledge since many of the mechanisms driving the rhythms in susceptibility to diseases, especially parasitic diseases, remain largely unknown," says Martin Olivier, Director of the Laboratory for the Study of Host-Parasite Interaction, a professor in McGill's Department of Microbiology and Immunology and co-author of the two studies.10.1016/j.isci.2024.

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