Compared with the general population, patients with erythropoietic protoporphyria have notably lower bone mineral density, although it improved with cholecalciferol supplementation.
have a higher prevalence of low bone mineral density than the general healthy population, but BMD improves with cholecalciferol supplementation.This longitudinal cohort study aimed to identify risk factors for low BMD in patients with EPP and assess factors associated with BMD improvement.
Researchers identified adult patients with EPP who visited the Erasmus Medical Center in Rotterdam, the Netherlands, and underwent at least one dual-energy x-ray absorptiometry scan. Data on BMD, vitamin D levels, and history of fractures were collected retrospectively from the medical records. The main outcome was BMD as assessed at the femoral neck and lumbar spine and reported as T-scores and Z-scores, which compare patient scores with scores of healthy young adults and age-matched adults, respectively.Low BMD was prevalent in patients with EPP, with 82.7% having a Z-score < 0 SD. Osteoporosis-related fractures were observed in 34.2% of patients.=.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Osteoporotic Bone Density Bone Mineral Density BMD Vitamin D Deficiency Vitamins Bones Erythropoietic Protoporphyria Bone Densitometry Dual Energy X-Ray Absorptiometry Backbone Back Bone Vertebral Column Spinal Column Fractures Spinal Fractures Fractures Of The Spine Spine Fractures Spinal Dislocation Dislocation Of The Spine Spine Dislocations Minerals Body Mass Index
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