An analysis of a large population of commercially insured children with juvenile idiopathic arthritis in the US showed an increasing popularity of more targeted therapies over the past two decades.
Researchers performed a serial cross-sectional study using Merative MarketScan Commercial Claims and Encounters data from 2000 to 2022 to describe recent trends in DMARD use for children with JIA in the United States.
They identified 20,258 new episodes of DMARD use among 13,696 children with JIA who newly initiated at least one DMARD. Participants were required to have ≥ 365 days of continuous healthcare and pharmacy eligibility prior to the index date, defined as the date of DMARD initiation.was the most commonly used DMARD throughout the study period ; however, as with other csDMARDs, its use declined from 42.1% in 2001 to 21.5% in 2022 (Use of the tumor necrosis factor inhibitor adalimumab doubled from 7% in 2007 to 14% in 2008 and increased further up to 20.
Even though the use of individual TNF inhibitors increased, their overall popularity fell in recent years as the use of newer b/tsDMARDs, such as"These real-world treatment patterns give us insight into how selection of therapies for JIA has evolved with increasing availability of effective agents and help prepare for future studies on comparative DMARD safety and effectiveness," the authors wrote.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Anti-Vax Doctor Simone Gold Sued by America's Frontline Doctors, the Group She Founded
RA - Rheumatoid Arthritis Rheumatoid Arthritis (RA) Disease-Modifying Antirheumatic Drugs Dmards DMARD Juvenile Rheumatoid Arthritis Juvenile Ra Juvenile Idiopathic Arthritis Arthritis Joint Inflammation Children Child Childhood Pediatrics Kids Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Biologic Therapy Biologics
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