Basing the treatment of gout on reaching and maintaining target serum uric acid level is already endorsed in guidelines, but a randomized trial finally showed the advantage with controlled data.
VIENNA — The first multicenter randomized trial in gout to compare treat-to-target and treat for symptom avoidance strategies has finally generated data to make the guideline-recommended practice of T2T evidence-based.
T2T is defined as maintaining a serum uric acid level below the physiologic threshold level of 36 mmol/L ( 30 kg/mFor those involved in the treatment of gout, this outcome was inevitable, according to Yael Klionsky, MD, a clinical assistant professor of rheumatology and immunology at Wake Forest University School of Medicine, Winston-Salem, North Carolina.
"Primary care physicians often do not recognize the importance of controlling serum uric acid or the goals of treatment," she told. For those who know this field, T2T does not need validation. She did not doubt that the ACP will change its position on T2T when its guidelines are updated. There was general agreement among the 151 rheumatologists, 150 nephrologists, and 102 primary care physicians that the absence of flares was among the top three criteria, but only 30% of primary care physicians and 35% of nephrologists vs 64% of rheumatologists identified the T2T target of < 0.36 mmol/L as one of the top three criteria.
Hyperuricemia Hyperuricaemia Clinical Guidelines Guidelines Treatment Guidelines Primary Care Remission Pain Pain Management Body Mass Index BMI Disability Europe European Immunology
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