Metformin Initiation Cuts Gout Risk in Prediabetes

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Metformin Initiation Cuts Gout Risk in Prediabetes
Diabetes Mellitus Type 2Diabetes Mellitus Type IiType 2 Diabetes
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Metformin use not only prevented the progression to diabetes but also lowered the risk for gout in individuals with prediabetes.

Individuals with prediabetes not only are at an elevated risk for diabetes but also face an increased risk for incident gout. Many previous reports have demonstrated the efficacy of antidiabetic medications in reducing the risk for gout in adults with diabetes.

The results were consistent across different subgroups stratified on the basis of sex, age , estimated glomerular filtration rate (≥ 90 vs < 90 mL/min/1.73 m Metformin initiation was not associated with significant changes in serum urate or C-reactive protein levels.Although gout is more commonly observed in men, around 60% of the study population consisted of women. Owing to the observational nature of this study, exposure misclassifications might have occurred.

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