Researchers led by Genshiro Sunagawa at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have shown that an animal's stem cells possess the same level of cold resistance as the animal itself.
, the study focuses on mice with different hibernation-like characteristics, showing that those with the best resistance to cold temperatures have stems cells that generate energy differently than others.as a practical model system for further research into organ preservation and even human hibernation.cold temperatures
eventually cause irreparable damage. At the same time, hibernating animals can survive for months with low body temperature because their metabolism becomes extremely slow. Sunagawa and his team at the RIKEN BDR Laboratory for Hibernation Biology are trying to understand how an animal, or just its organs, can survive under these conditions.because genetic variables can be controlled.
Although mice do not actually hibernate, they can enter a short one-hour hibernation period called torpor. The researchers tested strains of inbred laboratory mice and characterized torpor by the lowest body temperature and the lowestThey found one strain with shallow torpor, one with deep torpor, and one in between. They then established embryonic stem cell lines from each mouse strain and examined cell metabolism at around mouse body temperature and a cold temperature .
The energy that cells, and therefore animals, need to survive is produced in two ways. One way, called glycolysis, involves breaking down sugar molecules. This process does not require oxygen, and we can feel its byproduct in our muscles when we exercise and use up our available oxygen. The other way, calledThe researchers found that stem cells from the shallow- and medium-torpor mice switched to glycolysis at the colder temperature, while the stem cells from the deep-torpor mice did not.
Lastly, the researchers asked whether what they learned from the stem cells was actually relevant in adult mice. They examined
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