New Cleveland Clinic research shows how mosquito-transmitted viruses—like Zika, West Nile, Yellow Fever and dengue viruses—hijack host cells to promote their own replication and infection. Published in Cell Host and Microbe, a recent study from the laboratory of Michaela Gack, Ph.D., Scientific Director of Cleveland Clinic's Florida Research & Innovation Center, opens the door to developing new therapeutics for flaviviruses, a class of viruses for which either no or very limited treatments currently exist.
New Cleveland Clinic research shows how mosquito-transmitted viruses—like Zika, West Nile, Yellow Fever and dengue viruses—hijack host cells to promote their own replication and infection. Published in, a recent study from the laboratory of Michaela Gack, Ph.D., Scientific Director of Cleveland Clinic's Florida Research & Innovation Center, opens the door to developing new therapeutics for flaviviruses, a class of viruses for which either no or very limited treatments currently exist.
"Our findings bring us one step closer to understanding and treating currently untreatable mosquito-transmitted pathogens, which are an ever-increasing threat to global human populations," says Dr. Gack."Our commitment to studying viral pathogens and host enzymes in novel ways may ultimately help us develop new, effective treatments to prevent future threats toDr.
"Viruses mutate so much that drugging them directly might lose effectivity over time—this is what is known as antiviral drug resistance. Human proteins don't change rapidly," explains the study's second author Cindy Chiang, Ph.D."Targeting the host's KAT5γ protein should be much more effective in the long term to treat these viruses."
The study's findings suggest that creating drugs targeting the human KAT5γ enzyme might help target not only Zika, but also several other mosquito-transmitted flaviviruses.Taryn Serman et al, Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication,
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