The good news is that the risk for thyroid cancer linked to GLP-1 drugs appears low, but higher detections in the first year, when a causative role of the drug is implausible, suggested stepped-up screenings that could add to problems of over-detection.
New research, with the caveat of a relatively short follow-up, adds to encouraging data showing an overall low risk of the development of thyroid cancer associated with glucagon-like peptide 1 receptor agonist treatment.
More recent studies showing GLP-1 receptors in human papillary thyroid cancer cells has further raised concerns of a risk beyond medullary thyroid cancer, however, recent studies evaluating the risk have been inconclusive. The modified intention to treat analysis concluded no increase with GLP-1 RA use in thyroid cancer risk compared with the other three diabetes drugs .Importantly, the risk for thyroid cancer was significantly higher within the first year after GLP-1 RA initiation and was also higher among patients who stayed on the medication and didn’t add other medication .
In support of that theory, the study showed that those in the GLP-1 group had a significantly higher rate of receiving thyroid ultrasounds than those in the non−GLP-1 group, at 1.2% at 6 months for GLP-1RA initiators vs 0.8% for non−GLP-1 RA initiators, and an estimated 2.1% at 12 months for GLP-1RA initiators vs 1.5% for non−GLP-1RA initiators , and the risk beginning 1 year after treatment initiation was lower, at 0.83.
Meanwhile, thyroid testing is currently not recommended for patients on GLP-1s who do not have a thyroid cancer risk, and the results from the current and Pasternak’s studies, as well as several other recent studies, appear to support those recommendations. She underscored that overdiagnosis can have important implications, sharing her own personal experience on the receiving end of a cancer diagnosis.
Thyroid Carcinoma Cancer Of The Thyroid Malignant Head And Neck Neoplasm Head And Neck Cancer Head And Neck Cancer (HNC) Thyroid Disorder Thyroid Disease Thyroid Dysfunction Medullary Thyroid Carcinoma Medullary Carcinoma Of The Thyroid Otolaryngology ENT Specialty Head And Neck Surgery ENT Speciality Papillary Carcinoma Of The Thyroid Papillary Thyroid Carcinoma
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