Cartilage cells that contain fat explain why some skeletal tissues are less rigid than others, and could one day be grown in labs to produce better materials for performing reconstructive surgeries and rhinoplasties.
Cartilage transplants are central to many procedures, being used to fix cleft palates, correct missing or misshapen ears, or to repair damage to someone’s larynx caused by cancer. They’re also common in elective nose augmentations. But the results aren’t always stellar. Surgeons often resort to transferring cartilage from the rib, which is stiff, or using silicone implants, with neither material matching the real thing.
His team began their investigation by looking at the cartilage that’s sandwiched between thin layers of mouse ear skin. A green dye that preferentially stains fatty molecules revealed a network of squishy blobs. They isolated these lipid-filled cells and analyzed their contents. All of your cells contain the same library of genes, but those genes aren’t always activated.
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