Disease severity, indicated by lupus nephritis, high CRP levels, and longer duration, negatively affects bone health in systemic lupus erythematosus; clinical remission seems to benefit bone health.
classes III and IV, U1-ribonucleoprotein antibodies, and longer disease duration were associated with lower areal bone mineral density , and active lupus nephritis was associated with osteoporosis.Researchers analysed data of a subcohort of patients from a prospective observational study to identify factors associated with BMD and the risk for osteoporosis.
They included 110 patients with SLE from a hospital in Berlin between July 2015 and January 2022 who fulfilled the American College of Rheumatology/ European League Against Rheumatism 2019 SLE classification criteria and had current or prior glucocorticoid treatment. The analysis included SLE disease activity and a standardised bone health assessment with the DEXA scan and trabecular bone score measurement according to national guidelines. BMD- and osteoporosis-related factors were assessed.Areal BMD, expressed as the lowest DEXA-derived T score at the lumbar spine , total hip, or femoral neck A composite osteoporosis outcome Overall, 41% and 35% of patients with SLE had osteoporosis and lupus nephritis, respectively."The identification of SLE-specific risk factors allows us to recognize patients at particular high risk for OP . This prompts us to suggest a thorough osteoporosis check-up in patients with high CRP , LN , or U1-RNP-antibodies," the authors wrote.This study was led by Edgar Wiebe, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, Berlin, Germany. It wasThis monocentric cohort study primarily involved White Caucasians, thereby limiting the generalisability of the findings to other patient groups. A potential selection bias may have resulted in overrepresentation of patients with more severe disease courses who were at a high risk for osteoporosis. The cross-sectional design limited the ability to establish causality between identified factors and outcomes.Open access funding was enabled and organised by Projekt DEAL. The prospective observational study received a joint funding from AbbVie, Amgen, Alfasigma, Almirall, Biogen, BMS, Chugai, Fresenius Kabi, Galapagos, GA Generic Assays, GSK, Hexal, Horizon Therapeutics, Lilly, Medac, Mundipharma, Novartis, Pfizer, Roche, Sanofi-Genzyme, and UCB. The authors declared having no conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see ourACR: Rheumatologists Help Reduce ED, Hospitalization CostsTime to Monitor Blood Hydroxychloroquine Levels in Systemic Lupus Erythematosus?
Systemic Lupus Erythaematosus SLE Systemic Lupus Erythematosus (SLE) UK Site Content United Kingdom Site Content United Kingdom UK Lupus Nephritis Bone Density Bone Mineral Density BMD Lupus Bones Osteoporosis Osteoporotic Remission C-Reactive Protein Bone Densitometry Dual Energy X-Ray Absorptiometry
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