The surprising theory why boys are diagnosed with autism more often than girls

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The surprising theory why boys are diagnosed with autism more often than girls
HealthMental HealthAutism
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Today's Video Headlines: 03/27/26

Scientists have pointed the finger at genetic and biological differences, as well as diagnostic biases, as reasons Y boys are so unlucky. You might remember from biology class that boys have an X and a Y chromosome, while girls have two X chromosomes.

The long-time assumption is that the second X chromosome — also called Xi — is largely silent.Overlooked organ may be the secret to a longer, cancer-free life — how to care for it Whitehead researchers suggest that the “inactive X” chromosome actually plays an active role in shaping gene expression across the genome, including many genes tied to autism. The theory — called the “female protective effect” — proposes that higher expression of certain regulatory genes from Xi allows girls to better buffer the effects of autism-associated mutations. In short, girls generally require a greater “genetic load” — more, larger or more severe genetic mutations — to develop autism.The Whitehead researchers believe the “female protective effect” extends to 17 other congenital and developmental disorders that primarily affect boys. “Many of the other congenital or developmental conditions we’re pointing to aren’t subject to diagnostic inequities in the way autism is,” Harvard-MIT MD-PhD student Maya Talukdar said.The study authors plan to further explore Xi to understand sex differences in disease to improve diagnosis and care. In the meantime, they warn that girls and women are frequently overlooked or diagnosed late with autism. They say that one reason is that much of autism research — and the screening tools born from this research — has long focused on boys.include trouble making eye contact, difficulty understanding others’ feelings, struggles making friends, repetitive movements, obsessive interest in specific objects and sensory issues. If you suspect you might have autism, you should consider consulting a doctor or mental health professional for a formal diagnosis or referral. Hundreds of protesters swarm proposed NYC men's homeless shelter site, physically block construction truck Oil heir ordered to pay historic $1.1B after brutally attacking toddler stepson, putting him in wheelchairStream It Or Skip It: 'Jo Nesbø's Detective Hole' On Netflix, Where A Troubled Detective Tracks Down A Serial Killer Who Is Terrorizing Oslo

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