Drs Akshay Jain and Athena Philis-Tsimikas discuss results from the QWINT studies of insulin efsitora.
Greetings from Chicago. I'm Akshay Jain, endocrinologist from Vancouver, Canada . Joining us at the ADA 85th Scientific Sessions today, we've got a very special guest, Dr Athena Philis-Tsimikas, who is the corporate vice president at Scripps in San Diego. Welcome. It's a good question, because we have so many amazing new drugs that have come out and that we're seeing here at the ADA this year.
Despite having this fixed-dose adjustment, there was no increase in the level 1 or the level 2/level 3 combined hypoglycemia episodes. It's interesting because in all the other trials of once-weekly insulin, level 1 with icodec and efsitora, both were slightly more elevated in those groups. It’s very interesting that in the fixed-dose implementation we did not see that difference. I think that's remarkable. The safety is very important. It's paramount.
With efsitora, it was three times what the calculated weekly dose was. You take your daily dose, multiply it by seven to get your weekly dose, and then by three for that one-time starting dose. Icodec was similar in that you had to take it times seven, but then one and a half times, so you gave a 50% extra dose.
Diabetes Mellitus Type I Type 1 Diabetes Type 1 DM T1DM T1D Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus (T1DM) Hypoglycemia Canada Canadian Fellowship Fellows Residency Residents Patient Safety Primary Care Europe European Blood
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