A recent study reveals the pivotal role of tristetraprolin (TTP), an RNA-binding protein, in regulating inflammatory responses in basophils, immune cells central to allergic reactions. The research shows that TTP controls the stability of mRNAs for inflammatory molecules, preventing their overproduction.
A recent study reveals the pivotal role of tristetraprolin , an RNA-binding protein, in regulating inflammatory responses in basophils, immune cells central to allergic reactions. The research shows that TTP controls the stability of mRNAs for inflammatory molecules, preventing their overproduction. Using TTP-deficient mice, the team found heightened allergic inflammation, suggesting TTP as a promising therapeutic target for treating allergic and inflammatory diseases.
To address this gap, a group of researchers from Institute of Science Tokyo, led by Professor Kensuke Miyake, conducted a study to explore the role of tristetraprolin , an RNA-binding protein, in regulating inflammatory responses in basophils. Published inon November 15, 2024, the study reveals that TTP promotes the degradation of mRNAs encoding inflammatory cytokines and chemokines, thereby controlling basophil inflammatory responses.
Miyake states,"By promoting the degradation of mRNA for inflammatory molecules, TTP prevents their overproduction. In the absence of TTP, mRNA remains stable for a longer period, leading to excessive cytokine production and exacerbated allergic responses." This research underscores TTP as a key regulator of inflammatory responses in basophils and suggests that targeting TTP or its pathways could lead to new strategies for treating allergic diseases like asthma and atopic dermatitis.
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